1. The people in the novel are affected by the deletrium in different ways. Age is a big factor in their reactions; how do children, adults, and the elderly react differently and why?

2. What do you think the point of the Davis and Dean Bookstore is? How does it function in the story? Is there any thematic relationship between the presence of a chain bookstore and a story about memory?

3. What is the role of humor in the novel?

4. There are lot of minor characters whose stories are touched on in the novel (the manager, Lorna Hansen, Lilith, Ms. Plum). What do they add to the novel?

5. What do you think the function is of the scenes with the school-age children?

6. There are a number of points in the novel where the narrator breaks into the story and makes comments and addresses the reader. Why do you think the author chose that device?

7. Many novels consider the relationship between past and present. How is this novel different?

8. Before the chemical spill, how did the characters deal and not deal with their pasts? How did their pasts affect their choices?

9. In his lecture on memory, Bennie says that forgetting may be biologically positive. Do you think that’s true? Does the novel prove his point or not?

10. When Bennie sees Phil crying in his office, he thinks, "Our friendship does not encompass moments like these." What is the nature of their friendship? Phil is Bennie’s only real friend in Clarence -- why do you think that is? Why does Bennie let himself have a friend at all?

11. What is the effect of the glimpses of Susannah’s favorite television show, Innocence Falls?

12. What attracts Susannah and Madeline to each other initially? What draws them so close after the spill?

13. Why does Susannah move to Sunny Shadows? What is she running away from and what is she running toward?

14. What assumptions about memory does Todd make with his memory game? What leads him ultimately to destroy it?

15. Near the end of the novel, Sophie tells her father, "I’m just a kid." Why does she feel compelled to say this?

16. Some readers have said they want to see Susannah and Bennie fall in love at the end of the book. What would that do to the story? Would you find that satisfying? Why do you think they do not?

17. What do you think Calvin toasts to in the very last paragraph of the book?

18. What does the book have to say about regret? How does regret influence the lives of each character?

19. What do you think the author is saying about the nature and function of memory?

20. What do you think would have happened to these characters without the deletrium spill? Are the residents of Clarence better off after the spill? How do you think having these memories helped or hurt each character?

21. What do you think of the choices Susannah and Bennie make at the end of the book? Given their pasts, how does each character seek fulfillment, and what are the sacrifices they make?